But fans of the idea of being the "Most Interesting" will not be disappointed, a new actor will star in the ads scheduled for the fall.
In his final ad, Goldsmith will board a one-way trip to Mars. His parting words for the ad -- "Stay thirsty my friends."
Watch the ad here, or below:
Goldsmith's character has become a pop culture icon, inspiring memes across the Internet and Halloween costumes, USA Today reported.
Parent company Heineken USA will not say who will be the new face or what the ads will look like, but said they will pair with the new sponsorship of the college football playoff.
Goldsmith has been on shows since the 1960s including "Bonanza," "Knight Rider" and "Dallas."
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