Heavy smoke was coming from the hood of the semi and a man and woman inside were partially trapped when crews arrived, Huber Heights police said.
One crash victim was flown by CareFlight to Miami Valley Hospital and a second victim was taken by ambulance to a local hospital for treatment. Their names and conditions were not released.
Speed does not appear to be a factor in the crash, which remains under investigation police said.
Scanner traffic indicated the crash led to a diesel spill.
We are working to learn more and will update this story as more information is available.
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