Berger's Bakery was also closed after the health department saw flies in one of its display cases, WJZ reports.
A pest control company worked on cleaning the market throughout the night.
Friday’s closure will “expedite” the work, Lexington Market said.
There are over 100 vendors at the Lexington Market, selling everything from fresh produce to seafood.
Founded in 1782, the market has seen its share of pest control problems.
Rodents were caught by TV news cameras inside the market in 1997, forcing the market to shut down, according to the Baltimore Sun.
The market also shut down due to a roach infestation in 2016.