He threw 50 of 91 pitches for strikes. Cincinnati manager David Bell said the efficient approach allowed him to let Overton become the first Reds starter this year to pitch into the seventh inning.
Luis Cessa got five straight outs and Art Warren pitched around a leadoff single, getting Daniel Vogelbach to ground into a game-ending double play.
Cincinnati has the worst record in the major leagues at 8-24; the Reds are 3-1 against Pirates and 5-23 against other teams.
Tyler Stephenson hit a second-inning single that drove in Mike Moustakas, who led off with a double, and hit a 401-foot home run into the left field bleachers in the fourth. Stephenson had three hits, raising his batting average to .349.
Colin Moran and Tyler Naquin hit RBI singles in the eighth off Duane Underwood Jr., who was activated from the 10-day injured list following a right hamstring strain that had sidelined him since April 8.
Pirates starter JT Brubaker (0-3) allowed two runs and four hits in five innings.
SMOOTH DEBUT
Cam Alldred, a 25-year-old left-hander, made his MLB debut for the Pirates in the sixth. Alldred retired Moustakas on a popout, threw a called third strike past Stephenson and retired Moran on a groundout. Alldred gave up a leadoff single in the seventh to Naquin, then was replaced by Heath Hembree.
“It was unbelievable. A lot of emotions going through my body,” Alldred said. “ I was really happy to see my family and friends come out and support me.”
A Batavia, Ohio native, Alldred piched for the University of Cincinnati from 2016-18. He was called up to the majors for the first time on Wednesday.
“I was fired up to see that we were playing (the Reds) next,” he said. “That was pretty cool to open against them.”
ROSTER MOVES
Pirates: Claimed RHP Tyler Beede off waivers from San Francisco, recalled INF Rodolfo Castro from Triple-A Indianapolis, optioned INF Cole Tucker and RHP Max Kranick to Triple-A and designated RHP Beau Sulser for assignment.
Reds: Selected the contract of RHP Robert Dugger from Triple-A Louisville, recalled RHP Jared Solomon from Louisville, optioned RHP Dauri Moreta to Triple-A and assigned LHP Phillip Diehl outright to Louisville.
TRAINER’S ROOM
Reds: RHP Lucas Sims (back spasms) was placed on the 15-day
injured list, retroactive to Wednesday.
Pirates: OF Jake Marisnick had left thumb surgery and will miss four to six weeks.
UP NEXT
Reds RHP Tyler Mahle (1-4, 6.46 ERA) is to start Friday against Pirates RHP Mitch Keller (0-4, 6.11).
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CaptionCincinnati Reds starter Connor Overton pitches against the Pittsburgh Pirates during the first inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionCincinnati Reds starter Connor Overton pitches against the Pittsburgh Pirates during the first inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionCincinnati Reds starter Connor Overton pitches against the Pittsburgh Pirates during the first inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionCincinnati Reds starter Connor Overton pitches against the Pittsburgh Pirates during the first inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionPittsburgh Pirates' Cam Alldred pitches against the Cincinnati Reds during the sixth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionPittsburgh Pirates' Cam Alldred pitches against the Cincinnati Reds during the sixth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionCincinnati Reds' Tommy Pham (28) and TJ Friedl, top, greet teammates after a 4-0 win over the Pittsburgh Pirates in a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionCincinnati Reds' Tommy Pham (28) and TJ Friedl, top, greet teammates after a 4-0 win over the Pittsburgh Pirates in a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionCincinnati Reds outfielders Tommy Pham, left, TJ Friedl (29) and Tyler Naquin (12) celebrate after the Reds defeated the Pittsburgh Pirates in a baseball game Thursday, May 12, 2022, in Pittsburgh. The Reds won 4-0. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionCincinnati Reds outfielders Tommy Pham, left, TJ Friedl (29) and Tyler Naquin (12) celebrate after the Reds defeated the Pittsburgh Pirates in a baseball game Thursday, May 12, 2022, in Pittsburgh. The Reds won 4-0. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionCincinnati Reds relief pitcher Art Warren, right, shakes hands with catcher Tyler Stephenson after the team's 4-0 win over the Pittsburgh Pirates in a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionCincinnati Reds relief pitcher Art Warren, right, shakes hands with catcher Tyler Stephenson after the team's 4-0 win over the Pittsburgh Pirates in a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionCincinnati Reds' Colin Moran hits an RBI single against the Pittsburgh Pirates during the eighth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionCincinnati Reds' Colin Moran hits an RBI single against the Pittsburgh Pirates during the eighth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionCincinnati Reds' Tyler Stephenson (37) is greeted by Kyle Farmer (17) after scoring on a double by Tyler Naquin during the eighth inning of a baseball game against the Pittsburgh Pirates on Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionCincinnati Reds' Tyler Stephenson (37) is greeted by Kyle Farmer (17) after scoring on a double by Tyler Naquin during the eighth inning of a baseball game against the Pittsburgh Pirates on Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionPittsburgh Pirates' Ben Gamel (18) twists away as he tries to evade the tag from Cincinnati Reds third baseman Brandon Drury after he was caught off first and then in in a rundown between first and second during the sixth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionPittsburgh Pirates' Ben Gamel (18) twists away as he tries to evade the tag from Cincinnati Reds third baseman Brandon Drury after he was caught off first and then in in a rundown between first and second during the sixth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionCincinnati Reds' Tommy Pham (28) scores next to Pittsburgh Pirates catcher Michael Perez on a Colin Moran hit during the eighth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionCincinnati Reds' Tommy Pham (28) scores next to Pittsburgh Pirates catcher Michael Perez on a Colin Moran hit during the eighth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionPittsburgh Pirates shortstop Rodolfo Castro, right, loses the ball after forcing out Cincinnati Reds' Matt Reynolds (4) at second during the seventh inning of a baseball game,Thursday, May 12, 2022, in Pittsburgh. TJ Friedl was safe at first. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionPittsburgh Pirates shortstop Rodolfo Castro, right, loses the ball after forcing out Cincinnati Reds' Matt Reynolds (4) at second during the seventh inning of a baseball game,Thursday, May 12, 2022, in Pittsburgh. TJ Friedl was safe at first. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionPittsburgh Pirates right fielder Jack Suwinski snares a line drive by Cincinnati Reds' Tyler Naquin during the fourth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionPittsburgh Pirates right fielder Jack Suwinski snares a line drive by Cincinnati Reds' Tyler Naquin during the fourth inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionCincinnati Reds third baseman Brandon Drury throws to first after forcing out Pittsburgh Pirates' Ke'Bryan Hayes at second on the front end of a double play hit into by Bryan Reynolds during the third inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionCincinnati Reds third baseman Brandon Drury throws to first after forcing out Pittsburgh Pirates' Ke'Bryan Hayes at second on the front end of a double play hit into by Bryan Reynolds during the third inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic
CaptionPittsburgh Pirates' Ke'Bryan Hayes, right, beats the tag by Cincinnati Reds first baseman Colin Moran on a pickoff attempt during the third inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
CaptionPittsburgh Pirates' Ke'Bryan Hayes, right, beats the tag by Cincinnati Reds first baseman Colin Moran on a pickoff attempt during the third inning of a baseball game Thursday, May 12, 2022, in Pittsburgh. (AP Photo/Keith Srakocic)
Credit: Keith Srakocic
Credit: Keith Srakocic