Sanford, who at times had been critical of policy decisions and actions of the President, became the second GOP lawmaker to lose a bid for re-election in the Congress in 2018, joining Rep. Robert Pittenger (R-NC), who lost his primary in May.
As of now, 56 sitting members of the House will not be back for the next session of Congress that begins in January of 2019 - two have been defeated, 32 decided not to run again, and 22 others are seeking a different elected office.
Of those 56 departures, 39 are Republicans, and 17 are Democrats.
Sanford's defeat came a week after Rep. Martha Roby (R-AL) was forced into a runoff, with voters in the Yellowhammer State still unhappy over her criticism of Mr. Trump - from before the 2016 election, when she questioned his fitness for office after the release of a Hollywood Access videotape that featured vulgar remarks by the President when talking about women.
While Mr. Trump's candidate won by defeating Sanford, not everything the President touched in South Carolina worked, as his endorsement of Gov. Henry McMaster (R) could not prevent McMaster from being forced into a runoff in the GOP primary. That next vote will be on June 26.
Meanwhile in Virginia, Republicans selected pro-Trump supporter Corey Stewart to run against Sen. Tim Kaine (D-VA) in November.
At Stewart's victory celebration, a chant of "Lock her up!" came from the crowd at one point, a reminder of more conservative direction that the GOP has taken in recent years in Virginia.
Kaine is seen as the strong favorite over Stewart in November.