Ono's son, Sean Ono Lennon, said in a statement that the medal was “an incredible honor.”
“The history and list of past recipients is truly remarkable. It makes me very proud to see her art appreciated and celebrated in this way," he said.
Ono, 91, has made few public appearances in recent years and is not expected to attend the July awards ceremony, at the MacDowell campus in Peterborough, New Hampshire. Ono's music manager, David Newgarden, will accept the award on her behalf.
Ono first became known as part of the avant-garde Fluxus movement of the 1960s, then reached international fame after meeting John Lennon, to whom she was married from 1969 until his death, in 1980. Their many collaborations included the songs “Give Peace a Chance,” “Imagine” and “Happy Xmas (War Is Over)," the basis for “War Is Over! Inspired by the Music of John & Yoko,” this year's winner of the Oscar for best animated short film.
Over the past 40 years, Ono has had a busy career as a visual and recording artist, her albums including "Season of Glass," "Starpeace" and "Take Me to the Land of Hell." She was recently the subject of a career retrospective at London's Tate Modern.