The motorcyclist, identified as James Garner, 68, of Clarksville, was not wearing a helmet at the time of the crash, according to police.
Officers responded to the area of U.S. 22 near Old 3C Highway around 3:50 p.m. Sunday.
A preliminary investigation revealed that 2003 Harley Davidson motorcycle heading west on U.S. 22 crossed the center line and was hit by head-on a 2018 Ford Escape driven by Gary Gabbard of Highland Heights, Kentucky, police said.
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The motorcyclist suffered fatal injuries. Gabbard and his 16-year-old passenger were not injured.
Anyone with information on the crash should call Sgt. Tim Rector at 513-925-2525.
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