The crash was reported at the intersection of Wayne Avenue and Hickory Street, near Keowee Street, around 8:40 a.m.
Police said the bus was full of students when the crash happened. Two students on the bus reported injuries and received treatment on the scene.
No injuries were reported by the occupants in the car that was also involved.
The crash is under investigation and police said they are not sure which driver was at fault.
Additional details were not available.
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