Madrid's victory could have been even more commanding, but Vinícius Júnior's casually taken second-half penalty was saved by Gianluigi Donnarumma.
Defending champion Paris Saint-Germain beat Chelsea 5-2 and tiny Bodø/Glimt is also in sight of the quarterfinals after a 3-0 win over Sporting Lisbon.
Arsenal drew 1-1 with Bayer Leverkusen.
Havertz haunts Leverkusen
Kai Havertz returned to haunt Bayer Leverkusen and seal a late draw for Arsenal.
The Germany international struck an 89th-minute penalty against the team where he started his career and leveled the round-of-16 first leg tie at BayArena.
“I know the stadium well and have taken many penalties from this spot,” said Havertz, who left Leverkusen for Chelsea in a $95 million deal in 2020.
Premier League leading Arsenal fell behind on Robert Andrich's goal just after halftime. But Malik Tillman fouled Noni Madueke in the box, and Havertz fired low past Janis Blaswich from the spot.
“The time between the penalty whistle and the penalty kick felt like an eternity," Havertz said. “But in the end, you have to be mentally present in those moments.”
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James Robson is at https://x.com/jamesalanrobson
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AP soccer: https://apnews.com/hub/soccer