"We are deeply saddened by the incident at one of our hotels in La Romana, Dominican Republic, and want to express our deepest condolences to their family and friends," Bahia Principe Hotels said in a statement, according to CNN.
Holmes had shared photos last week on social media of the couple on a boat ride and having a good time.
The incident follows another disturbing event in the Dominican Republic in January. A Delaware woman went public last week with a description of how she was beaten and left for dead at a resort in the country while on vacation with her husband and another couple. She was seriously injured in the attack and said she almost didn't survive.