His older siblings Bao Bao and Tai Shang made their journeys in 2017 and 2010, the Post reported.
Bei Bei leaves behind his parents, Mei Xiang and Tian Tian, and will be accompanied on the FedEX flight, dubbed "Panda Express" by a panda keeper and a veterinarian, WJLA reported.
He won't be able to roam the plane, but will be in a steel and Plexiglass enclosure with all of his toys and food he needs for the 16-hour flight, The Washington Post reported.
The zoo has been prepping for the trip for about two months, USA Today reported.
"The panda team will continuously monitor Bei Bei during the trip," the zoo said in an announcement, according to The Washington Post.
Once he arrives in China, he'll be taken to the Bifengxia Panda Base which is run by the China Conservation and Research Center for the Giant Panda, USA Today reported. The team will work with the team in China to help Bei Bei adjust.
For more on the zoo's giant panda program, click here.
To follow Bei Bei's journey, click here.