An alarm at the museum alerted police of the break-in around midnight Friday, according to a release from Wapakoneta police.
Officers discovered someone broke into the museum and stole the sold gold replica of the lunar module, which stands 5 inches tall and about 4.5 inches wide.
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"This piece is very rare as it was presented to Neil Armstrong in Paris, France, shortly after the moon landing," police said.
The piece is one of only three that were made, one for each of the astronauts who completed the mission, police said.
The FBI and the Ohio Bureau of Criminal Investigation assisting Wapakoneta police in the investigation.
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