"She's now with Carrie and we're all heartbroken," Fisher said from Cedars-Sinai Medical Center, where his mother was taken by ambulance earlier Wednesday.
He said the stress of his sister's death on Tuesday "was too much" for Reynolds.
Carrie Fisher, who was 60, had been hospitalized since Friday.
"She said, 'I want to be with Carrie,'" her son said. "And then she was gone."
<FULL REPORT: Actress Debbie Reynolds, 84, dies day after daughter
< VIDEOS: Debbie Reynolds, Carrie Fisher together in 2010 | Debbie Reynolds on Larry King Live