Investigators said the bus was stopped when an inattentive driver failed to stop, clipping a small Honda in the rear, sending it head-on into the school bus.
The bus, from the Clark Shawnee School District, was filled with elementary students, one of whom was slightly injured and taken to a local hospital for treatment.
Medics said the driver of the Honda was also taken to a local hospital for treatment.
Witnesses said the school bus driver was doing absolutely the right thing when it was hit.