Kluber limited Chicago to five hits in six innings, becoming the first pitcher to win Games 1 and 4 since Cincinnati’s Jose Rijo in 1990.
Santana’s homer off John Lackey and a run-scoring throwing error by third baseman Kris Bryant on Kluber’s infield hit gave Cleveland a 2-1 lead in the second.
Francisco Lindor added an RBI single in the third, Lonnie Chisenhall hit a sacrifice fly in the sixth off Mike Montgomery, and Chicago native Kipnis blew open the game with a three-run homer against Travis Wood in the eighth.