Davis allowed four runs on five hits with four strikeouts and two walks and exited with the Cincinnati trailing 4-1.
But the Reds tied the game with three runs in the fourth on an RBI single by Zack Cozart, a sacrifice fly by Stuart Turner and pinch-hitter Scooter Gennett’s RBI groundout.
Lorenzen came to the plate with two outs and no one on in the bottom of the sixth and drilled a 3-1 pitch from Adam Morgan to straight-away center field to put the Reds in front.
Adam Duvall added a two-run homer in the seventh, and five Cincinnati relievers limited the Phillies to one hit over the final six innings.
Cody Reed picked up his first big-league win despite walking four in two innings, and Drew Storen worked the ninth to earn his first save as a Red.
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