The Flyers beat the Buckeyes in the first round of the NCAA tournament in 2014.
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Ohio State last played Xavier in the regular season in 1935. The teams played in the NIT in 1984 and the NCAA tournament in 2007.
Ohio State played Cincinnati in the regular season in December 2006 in Indianapolis, and the teams played in the NCAA tournament in 2012.
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Holtmann, who was hired in June to replace Thad Matta, had success with Butler in the Crossroads Classic in Indianapolis. The annual four-team event features Butler, Indiana, Purdue and Notre Dame.
“I liked that,” Holtmann said. “I give Indiana a lot of credit, as well as Purdue, for playing in that event. You probably have a little more to lose if you’re sitting in that seat."