Anthony DeSclafani made his first start of the season for the Reds and allowed one earned run on three hits in five innings.
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The Brewers took a 1-0 lead in the third. Lorenzo Cain scored on a two-out single by Jesus Aguilar.
Brewers starter Jhoulys Chacin pitched three perfect innings before running into trouble in the fourth. Joey Votto started the rally with a walk. Yasiel Puig singled. Eugenio Suarez followed with a double, scoring Votto and tying the score.
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Zach Duke relieved DeSclafani in the sixth and left the game with two runners on base and two outs. Michael Lorenzen replaced him and gave up a three-run home run to the first batter he faced, Arcia.
The Reds scored their second run in the sixth. A groundout by Scott Schebler scored Joey Votto. Eugenio Suarez hit a home run in the eighth to cut Milwaukee’s lead to 4-3.
NOTES: Matt Kemp struck out in a pinch-hit appearance. He's 0-for-8 this season. … Scott Schebler went 0-for-4. He's 0-for-14. … Jesse Winker went 0-for-4. He's 0-for-9.