The driver and a passenger in the one of the vehicles were both trapped due to the crash, James added.
All four people were transported to area hospitals.
The crash involved a Chevrolet sedan that sustained significant front-end damage, and a landscaping company work truck pulling a trailer full of equipment.
It temporarily closed Wilmington Pike between Parklawn Drive and Bigger Road and East David Road between Bigger Road and Wilmington Pike.
The crash remains under investigation.
Assistant news editor Jeremy Kelley contributed to this report.
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