Police said the semi may have to be unloaded before it can be flipped upright.
No injuries have been reported.
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Police say it could take four or five hours to clear a semi-tractor trailer that flipped and is leaking fuel following a crash in Vandalia this afternoon.
Around 1:30 p.m., the semi crashed off Brown School Road at Little York Road. Officials are working to keep fuel out of a nearby creek after the semi came to a rest on its side. The trailer cracked open in the crash, and 2-liter plastic bottles that the semi was hauling is now scattered across the roadway.