Carlos Santana, Lane Thomas and David Fry hit solo home runs for Cleveland, which has dropped six straight and fell to 40-44.
Imanaga (5-2) gave up three earned runs in 5 1/3 innings and struck out four. Cleveland’s Tanner Bibee (4-9) allowing five earned runs in four innings.
The homers by Santana and Thomas came on consecutive pitches to begin the second inning, both landing in the left-field basket. Fry's homer made it 3-0 in the third, but the Cubs scored twice in the bottom of the inning before Suzuki's two-run single and Crow-Armstrong's triple made it 5-3 in the fourth.
Steven Kwan hit a sacrifice fly in the ninth, but Daniel Palencia recorded the final out to secure his 10th save.
Key moment
Suzuki's run-scoring double and Crow-Armstrong's RBI single in the third started Chicago's comeback.
Key stat
The Guardians were 0 for 4 with runners in scoring position and left seven runners on base. The Cubs had three hits with runners in scoring position.
Up next
Chicago RHP Cade Horton (3-2, 4.80 ERA) is slated to take the mound against Cleveland RHP Luis Ortiz (4-9, 4.36) on Thursday.
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AP MLB: https://apnews.com/hub/mlb
Credit: AP
Credit: AP
Credit: AP
Credit: AP