Eugenio Suárez went 2 for 4 and led off the third against Nick Martinez (4-6) with his 17th home run for the Diamondbacks' run.
Lux's grand slam came off reliever Kendall Graveman, who needed 33 pitches to end the fourth after coming in with two on and no outs.
Graveman gave up a single to Matt McLain to load the bases before hitting Friedl with a pitch to force in a run. Lux hit his next pitch out to right field for a 10-1 lead. De La Cruz doubled and scored on a Stephenson single in the eight-run inning. Stephenson finished 3 for 5 and scored twice.
Martinez allowed a run on six hits in six innings with six strikeouts. Joe La Sorsa, Brent Suter and Lyon Richardson pitched a scoreless inning to close.
Nelson (2-2) gave up seven runs in three innings. Graveman allowed six runs in an inning.
Key moment
Encarnacion-Strand's first-inning homer gave the Reds all the runs they needed to climb within a game of .500 at 32-33.
Key stat
Two of Lux’s three grand slams have come against Arizona. He hit his other two in 2021 while playing for the Dodgers.
Up next
RHP Zac Gallen (4-7, 5.13) was set to start Sunday for Arizona against Cincinnati RHP Brady Singer (6-4, 4.66) in th series finale.
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AP MLB: https://apnews.com/hub/mlb
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