They are aimed at people whose LDL cholesterol levels remain high even when they take the maximum dose of regular statin drugs as well as those who have familial high cholesterol.
Even with preapproval, patient copayments ranging from $0 to $2,822 per month discouraged many from filling their prescriptions, the study found.
Whether or not a patient picked up the prescription was driven almost entirely by the out-of-pocket cost, said Dr. Ann Marie Navar, a clinical cardiologist and researcher at Duke Clinical Research Institute who was the study’s lead author.
Compared with patients who had no copayment, people who had to pay $10 were 19 percent less likely to fill their prescription. People with a $100 copay were 84 percent less likely to do so, the study found.
The study, published online in JAMA Cardiology this week, analyzed pharmacy claims data for 45,029 patients who received a new PCSK9i prescription between August 2015 and July 2016. It was funded by Amgen, which makes Repatha.
Patients who have a hard time affording the cost of these drugs should investigate the drug companies’ copay-assistance programs, as 38 percent of patients in the study did, Navar said. However, those programs aren’t typically available to patients who are covered by public programs like Medicare and Medicaid.
Beyond that, Navar’s best advice for patients is to be persistent. “Most prescriptions are rejected on the first submission and not all of those are appealed,” she said.
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(Kaiser Health News (KHN) is a national health policy news service. It is an editorially independent program of the Henry J. Kaiser Family Foundation.)