Huffman had 53.3 percent to Bradley’s 46.7 percent of the vote.
Republican Sen. Steve Wilson, R-Maineville, defeated Democrat Sara Bitter in the 7th District, 62.1 percent to 37.9 percent.
RELATED: Plummer, Butler, Antani, Perales among winners in local Ohio House races
The Ohio Senate 5th District encompasses Miami, Preble, southern Darke and west-central Montgomery County.
RELATED: 10 things to watch in today's election
Huffman, a Republican physician from Miami County, will replace term-limited State Sen. Bill Beagle, R-Tipp City.
Beagle had taken the seat from Democrats in 2010 and then won re-election in 2014 after an expensive and controversial advertising campaign.
RELATED: Beagle ads continue bogus claim
Huffman argues that state taxes are too high and need to be reduced, and said he wants to “free the private sector of burdensome regulations.”
RELATED: Republican Smith narrowly defeats Foley in state 43rd House district race
Bradley, an administrator for Antioch University, focused on the other side of the economic equation, calling for “economic climate that provides good-paying jobs,” and said the state is due for a minimum wage increase.
VOTERS GUIDE: Bradley, Huffman run for state senate
Wilson, is former president and chairman of the board of Lebanon Citizens National Bank, who was appointed in 2017 to replace Shannon Jones after she resigned to run for Warren County commission.
RELATED: Democrat challenges appointed Republican in Warren County race
Bitter, is a lawyer and former assistant to former President Bill Clinton’s special counsel. She also served as national field director for the ReelAbilities Film Festival North America and co-chair of the 2015 Cincinnati event.
The Ohio Senate 7th district includes all of Warren and part of Hamilton counties.
Staff writer Lawrence Budd contributed to this report.
How do we get the economy to boom for all?
Jobs expert: ‘This is going to be an epidemic’
Debate focuses on Guns At Work
7 things to know about Dayton’s economy
These jobs are expected to see the highest demand in Ohio through 2024
Ohio governor candidates: Where they stand on jobs and the skills gap
Ohio Chamber of Commerce calls for BOLD innovation in the state