Here are seven things to know about the game:
1. Ohio State dominated statistically.
The spread in points did not really reflect the difference in the teams most of the night.
The Buckeyes jumped out to a 21-3 lead but Penn State hung around as Ohio State failed to score in the red zone twice and gave up three touchdowns in the second half.
Ohio State finished with a 526-325 advantage in total yards, including a 208-44 lead in the ground game.
2. Justin Fields was awesome again.
Ohio State’s junior quarterback completed 28 of 34 passes for 318 yards and four touchdowns at Penn State after completing 20 of 21 for 276 yards and two touchdowns in the season-opening win over Nebraska.
He completed passes to eight different receivers and seemed to have an answer to anything Penn State did all night.
Fields was 6-for-7 for 77 yards on third downs and completed four passes of 20 yards or more.
3. So were Chris Olave and Garrett Wilson.
For the second game in a row and fourth time in school history, Ohio State had a pair of receivers go over 100 yards receiving.
Olave caught seven passes for 120 yards and two touchdowns, scoring from 26 and 49 yards out.
Wilson hauled in 11 passes for 111 yards. Four of his receptions came on successful third down conversions, and he had a 62-yard run on the first play from scrimmage.
4. The Ohio State secondary struggled in the second half.
Penn State quarterback Sean Clifford struggled to find and hit receivers in the first half but had a strong final 30 minutes until a game-sealing interception by Pennsylvania native Marcus Hooker.
Utilizing run-pass options and fade routes mostly with some crossers mixed in, Clifford ended up 18 for 30 for 281 yards and three touchdowns.
Jahan Dotson caught all the scores and five other passes to finish with 144 yards while Parker Washington caught four passes for 73 yards.
Dotson did much of his damage against Shaun Wade, Ohio State’s top corner. That included a pair of circus catches in the fourth quarter as the Nittany Lions attempted a comeback.
No one in the secondary was credited with a pass breakup other than Hooker, a sophomore safety.
Ohio State also lost cornerback Cam Brown to an apparent injury in the second half.
5. Master Teague III looked better than week one.
The sophomore bruiser netted 110 yards on 23 carries, nearly tripling his Week 1 output of 41 yards. Teague averaged 4.8 yards per carry after going for just 3.4 against Nebraska.
He hit holes hard and finished runs, though the Nittany Lions were able to bottle him up in the fourth quarter when the Buckeyes were trying to salt the game away.
6. Ohio State dominated the game on both lines.
The Buckeyes were stout enough up front on defense that Penn State essentially abandoned the running game right away. Running back Devyn Ford had eight carries for 36 yards while Clifford was held in check (five yards after sacks were figured in) after running for more than 100 yards in a Week 1 loss to Indiana.
The Ohio State offensive line also had its way with Penn State most of the night, clearing the way for 208 yards rushing and giving up just two sacks and little pressure to a team with several talented pass rushers.
7. The Buckeye defensive line made plays.
Nose tackle Tommy Togiai had three sacks and led the team with seven tackles.
He helped clog the middle while felling tackle Haskell Garrett was also active inside again.
Jonathon Cooper was a disruptive force off the edge and shared a sack with Zach Harrison while Javontae Jean-Baptiste also had a sack.