Recently though, some new research leads have turned up potentially promising approaches. One that Sanofi already uses relies on cell cultures, rather than eggs, to develop vaccines because some viruses do not reproduce as well in eggs. That was a problem, for instance, with this year’s vaccine against the H3N2 strain, some experts maintain. Scientists have also developed ways to use what’s known as recombinant DNA technology in the production of cell-based vaccines. That allows them to find individual genes on a virus that are more likely to stimulate an immune response, cut them out, and insert them into the genome of another organism to make a more successful vaccine.
Even using such advanced techniques, a flu vaccine with 90 percent effectiveness may be beyond reach, given the scientific challenges of targeting the virus over time. Shiver imagines that even a universal shot, were it to be successfully developed, would have to be constantly tweaked.
“We don’t know the best way to produce them, which is why, at Sanofi Pasteur, we’ve been accumulating technology for flexibility,” he said.
Johnson & Johnson’s Janssen research group is also doing pre-clinical work on a universal vaccine. “New innovations for influenza are urgently needed,” said Julian Symons, research and development leader of respiratory infections.
GlaxoSmithKline, another leading vaccine developer, is conducting one of the first studies of a universal flu vaccine in humans. The shot is based on research directed in part by Peter Palese, the chair of microbiology at Mount Sinai’s Icahn School of Medicine in New York. Unlike current vaccines that target constantly changing proteins on the surface of the flu virus, Palese’s approach targets a part of the virus that remains relatively stable from year to year. Glaxo is lending expertise in boosting the immune response through vaccination, particularly because that region of the virus doesn’t typically elicit a big immune response.
Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, says an effective universal flu vaccine would outsell the seasonal one. The annual vaccine brought in $2.4 billion for Sanofi and GSK in 2017 alone. Vaccines can be big business for pharma companies: Pfizer Inc.’s Prevnar, which prevents certain forms of pneumonia, was its top-selling product last year, bringing in $5.6 billion. Other lucrative vaccines include Merck & Co.’s $2.3 billion-in-sales Gardasil, which protects against the human papillomavirus, and Sanofi’s vaccine against polio and whooping cough, also about a $2 billion-a-year business.
To have a crack at those sorts of numbers, some experts say the push for a universal flu vaccine is going to require stepped-up investment.
“If you look at the resources that are now dedicated to the universal influenza vaccine, it’s really small across the world, so there certainly needs to be mobilization,” said Wayne Koff, chief executive officer and president of the Human Vaccines Project, an organization that seeks to speed up vaccine development. Koff previously worked at the International AIDS Vaccine Initiative and sees parallels between the two viruses. When the public stepped up its efforts to fight HIV and AIDS, the research community received much-needed funding to develop the antivirals that have since transformed the way HIV is treated.
Some lawmakers are heeding the call. Sen. Ed Markey, D-Mass., introduced the Flu Vaccine Act this month, which would provide $1 billion over five years to fund efforts by the National Institutes of Health to develop a universal flu vaccine. By comparison, Fauci’s division within NIH spent an estimated $64 million on such research in fiscal 2017.
Even the most dedicated researchers say results won’t come overnight, and people should keep taking the seasonal flu shot for now.
“This system prevents a lot of disease, and it is our best tool,” said Leonard Friedland, director of scientific affairs for vaccines in North America at GSK. “Would we like to have vaccines which would be more effective? Of course we would. But if it were easy, it would’ve been done.”
—With assistance from Karishma Motwani