Springboro Detective Drew Pyles said it was possible that Andrews could have been harmed or be unable to care for herself.
Andrews, 15, of Springboro ran away from home on Wednesday, according to police.
She is described as a white female, 5-feet, 6 inches tall and weighing 140 pounds, with brown hair and blue eyes.
Anyone with information about her whereabouts is to call 937-748-0611 and ask for Pyles.
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