Dayton police were dispatched to the crash at around 3:45 a.m. Saturday on Interstate 75 near Salem Avenue.
On investigation, police said that they found a gray Honda Accord was involved in a hit-and-run crash, then got on I-75 driving the wrong way in the southbound lanes.
The car crashed into a white Ford Transit.
The driver of the Honda, later identified as Pernell, was pronounced dead at the scene.
Two men in the Ford were transported to the hospital, where they were treated and released later the same day.
This case remains under investigation by the Dayton Police Department.
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